vicissitude
[noun]
Synonyms: change, innovation, mutation, novelty, permutation, sport, difficulty, asperity, hardness, hardship, rigor

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Related Words: alternation, reversal, transposition, progression, diversity, variety, chop and change, ups and downs, adversity, mischance, misfortune, affliction, trial, tribulation

[TahlilGaran] English Synonym Dictionary ▲

vicissitude noun

1. one of the many changes and problems in a situation or in your life, that you have to deal with
   • ● the vicissitudes of family life
   Word Originearly 17th cent. (in the sense ‘alternation’): from French, or from Latin vicissitudo, from vicissim ‘by turns’, from vic- ‘turn, change’.

[TahlilGaran] English Dictionary ▲